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阻塞性黄疸狒狒骨骼肌对注入去甲肾上腺素的血管舒缩反应受损。

Impaired skeletal muscle vasomotor response to infused noradrenaline in baboons with obstructive jaundice.

作者信息

Bomzon L, Wilton P B, McCalden T A

出版信息

Clin Sci Mol Med. 1978 Jul;55(1):109-12. doi: 10.1042/cs0550109.

DOI:10.1042/cs0550109
PMID:97041
Abstract
  1. We have measured muscle blood flow by a 133Xe clearance technique, and its response to noradrenaline in baboons before and 2 weeks after ligation of the bile ducts when they were jaundiced. 2. In the normal baboons, the response to noradrenaline was a dose-dependent decrease in muscle blood flow. 3. Bile-duct ligation caused no significant alteration in skeletal muscle blood flow but the response to noradrenaline in the jaundiced baboons was significantly attenuated. This effect was not observed in four sham-operated baboons.
摘要
  1. 我们采用¹³³氙清除技术测量了狒狒在胆管结扎前及结扎后2周黄疸状态下的肌肉血流量及其对去甲肾上腺素的反应。2. 在正常狒狒中,对去甲肾上腺素的反应是肌肉血流量呈剂量依赖性减少。3. 胆管结扎未引起骨骼肌血流量的显著改变,但黄疸狒狒对去甲肾上腺素的反应显著减弱。在4只假手术的狒狒中未观察到这种效应。

相似文献

1
Impaired skeletal muscle vasomotor response to infused noradrenaline in baboons with obstructive jaundice.阻塞性黄疸狒狒骨骼肌对注入去甲肾上腺素的血管舒缩反应受损。
Clin Sci Mol Med. 1978 Jul;55(1):109-12. doi: 10.1042/cs0550109.
2
Modification of the cerebrovascular response to noradrenaline by bile duct ligation.胆管结扎对脑血管去甲肾上腺素反应的影响
Gut. 1975 Sep;16(9):732-7. doi: 10.1136/gut.16.9.732.
3
Renal blood flow in obstructive jaundice: an experimental study in baboons.梗阻性黄疸时的肾血流量:狒狒的实验研究
Clin Exp Pharmacol Physiol. 1976 Sep-Oct;3(5):461-72. doi: 10.1111/j.1440-1681.1976.tb00624.x.
4
Abnormal cerebrovascular response to altered PaCO2 in baboons with obstructive jaundice.阻塞性黄疸狒狒对PaCO2改变的脑血管反应异常。
Stroke. 1976 Mar-Apr;7(2):190-3. doi: 10.1161/01.str.7.2.190.
5
The effect of dopamine on renal cortical blood flow in baboons with experimentally induced obstructive jaundice.多巴胺对实验性诱导梗阻性黄疸狒狒肾皮质血流的影响。
Isr J Med Sci. 1978 Oct;14(10):1069-72.
6
Renovascular hypersensitivity to noradrenaline in dietary-induced hypercholesterolaemia in baboons.狒狒饮食诱导的高胆固醇血症中肾血管对去甲肾上腺素的超敏反应。
Clin Exp Pharmacol Physiol. 1978 Mar-Apr;5(2):181-5. doi: 10.1111/j.1440-1681.1978.tb00668.x.
7
Bile salts, obstructive jaundice and renal blood flow.胆汁盐、梗阻性黄疸与肾血流量
Isr J Med Sci. 1979 Feb;15(2):169-71.
8
Effects of experimental obstructive jaundice on contractile responses of dog isolated blood vessels: role of endothelium and duration of bile duct ligation.实验性梗阻性黄疸对犬离体血管收缩反应的影响:内皮的作用及胆管结扎持续时间
Clin Exp Pharmacol Physiol. 2000 May-Jun;27(5-6):339-44. doi: 10.1046/j.1440-1681.2000.03256.x.
9
The effects of jaundiced plasma and hypercholesterolaemic plasma on vascular sensitivity to injected noradrenaline.
Experientia. 1975 Oct 15;31(10):1173-4. doi: 10.1007/BF02326776.
10
The effect of phenoxybenzamine and saralasin on the altered renal blood flow distribution in baboons with obstructive jaundice.苯苄胺和沙拉新对阻塞性黄疸狒狒肾血流分布改变的影响。
Clin Exp Pharmacol Physiol. 1977 Jul-Aug;4(4):365-73. doi: 10.1111/j.1440-1681.1977.tb02674.x.

引用本文的文献

1
The effect of jaundiced sera and bile salts on cultured beating rat heart cells.黄疸血清和胆汁盐对培养的大鼠跳动心脏细胞的影响。
Experientia. 1983 Nov 15;39(11):1307-8. doi: 10.1007/BF01990384.
2
Decrease in peripheral sympathetic nervous system activity following renal denervation or unclipping in the one-kidney one-clip Goldblatt hypertensive rat.肾去神经支配或解除单肾单夹型戈德布拉特高血压大鼠的肾夹后外周交感神经系统活性降低。
J Clin Invest. 1982 Jan;69(1):55-62. doi: 10.1172/jci110441.