Berkhout B
Department of Human Retrovirology, Academic Medical Center, Amsterdam, The Netherlands.
J Biomed Sci. 1999 Sep-Oct;6(5):298-305. doi: 10.1007/BF02253518.
The human immunodeficiency virus (HIV-1) has evolved into a viral quasispecies with a high replication capacity or fitness. Antiretroviral drugs potently inhibit replication of the wild-type virus, but HIV-1 responds by selection of drug-resistant variants. Here we review, in brief, the evolution of resistance to protease inhibitors that is characterized by severe fitness losses and an abundance of subsequent repair strategies. The possibility to restrict HIV-1 fitness is discussed in relation to the control of HIV-1 pathogenesis.
人类免疫缺陷病毒1型（HIV-1）已演变成具有高复制能力或适应性的病毒准种。抗逆转录病毒药物可有效抑制野生型病毒的复制，但HIV-1会通过选择耐药变异体来做出反应。在此，我们简要回顾对蛋白酶抑制剂耐药性的演变，其特征是严重的适应性损失以及大量后续修复策略。我们还讨论了限制HIV-1适应性的可能性与HIV-1发病机制控制之间的关系。
