Graham D I, Horsburgh K, Nicoll J A, Teasdale G M
Department of Neuropathology, University of Glasgow, Scotland, UK.
Acta Neurochir Suppl. 1999;73:89-92. doi: 10.1007/978-3-7091-6391-7_15.
Apolipoprotein E (apoE) is an important part of the means by which lipids are transported in the nervous system. This transport system provides injured nerve cells, the cholesterol and phospholipids for the maintenance and repair of membranes, the growth of neurites, dendritic remodelling and synaptogenesis, and the effect of injury to the nervous system is now known in part to be modulated by the various isoforms of apoE. After the demonstration of an association between the apoE epsilon 4 and increased risk of subsequent development of both sporadic and late-onset form Alzheimer's disease, recent studies have provided additional evidence for the possibility that apoE may play an isoform-specific role in determining both the initial response and the subsequent consequences to acute brain injury. Further studies are required to better understand not only the response(s) of the nervous system to injury, but also the relationship between acute injury to the brain and the subsequent development of neurodegenerative disorders.
载脂蛋白E（apoE）是脂质在神经系统中运输方式的重要组成部分。该运输系统为受损神经细胞提供维持和修复细胞膜、神经突生长、树突重塑和突触形成所需的胆固醇和磷脂，并且目前已知神经系统损伤的影响部分受apoE的各种亚型调节。在证实apoE ε4与散发性和晚发性阿尔茨海默病后续发病风险增加之间存在关联后，最近的研究提供了更多证据，表明apoE可能在决定急性脑损伤的初始反应和后续后果方面发挥亚型特异性作用。不仅需要进一步研究以更好地理解神经系统对损伤的反应，还需要研究脑急性损伤与神经退行性疾病后续发展之间的关系。
