Poirier J
Douglas Hospital Research Centre, Verdun, Quebec, Canada.
J Psychiatry Neurosci. 1996 Mar;21(2):128-34.
Recent evidence indicates that apolipoprotein E (apoE) plays a central role in the brain response to injury. The coordinated expression of apoE and its main receptor, the apoE/apoB (LDL) receptor, appears to regulate the transport of cholesterol and phospholipids during the different phases of the reinnervation process. The recent discovery that a peculiar form of apoE, the apoE4, is strongly linked to both sporadic and familial late onset Alzheimer's disease (AD) raises the possibility that a dysfunction of the lipid transport system associated with compensatory sprouting and synaptic remodelling could be central to the AD process. The role of apoE in the central nervous system (CNS) is particularly important in relation to the function of the cholinergic system which relies to a certain extent on the integrity of phospholipid homeostasis in neurons. Recent evidence suggests that apoE4 allele has a direct impact on cholinergic function in AD.
最近的证据表明，载脂蛋白E（apoE）在大脑对损伤的反应中起核心作用。apoE及其主要受体apoE/apoB（低密度脂蛋白）受体的协同表达似乎在神经再支配过程的不同阶段调节胆固醇和磷脂的转运。最近发现一种特殊形式的apoE，即apoE4，与散发性和家族性晚发性阿尔茨海默病（AD）密切相关，这增加了一种可能性，即与代偿性发芽和突触重塑相关的脂质转运系统功能障碍可能是AD发病过程的核心。apoE在中枢神经系统（CNS）中的作用对于胆碱能系统的功能尤为重要，胆碱能系统在一定程度上依赖于神经元中磷脂稳态的完整性。最近的证据表明，apoE4等位基因对AD中的胆碱能功能有直接影响。
