Miller A M, Miller R B, Obermeyer W H, Behan M, Benca R M
Neuroscience Training Program, University of Wisconsin-Madison, 53719, USA.
Behav Neurosci. 1999 Aug;113(4):755-65. doi: 10.1037//0735-7044.113.4.755.
A variety of sensory stimuli (e.g., visual, auditory, and thermal) are known to induce rapid eye movement (REM) sleep in mammals. Studies have examined the induction of REM sleep in albino rats by light-to-dark transitions, a phenomenon referred to as REM sleep triggering. Recent research has demonstrated that aspiration lesions of the superior colliculus (SC) and pretectal area attenuated REM sleep triggering. To define more specifically the area or areas involved in mediating REM sleep responses to changes in illumination, fiber-sparing neurotoxic lesions were made to the pretectum (PT) or the SC. Lesions of the PT attenuated REM sleep triggering, whereas lesions of the SC did not. Thus, the role of the PT may be expanded to include the regulation of REM sleep in response to photic stimulation in albino rats. These findings provide a paradigm in which to study mechanisms of REM sleep generation and the effects of light on behavioral state.
已知多种感觉刺激（如视觉、听觉和热刺激）可在哺乳动物中诱发快速眼动（REM）睡眠。研究已经通过从亮到暗的转变来研究白化大鼠中REM睡眠的诱发，这一现象被称为REM睡眠触发。最近的研究表明，上丘（SC）和顶盖前区的抽吸性损伤减弱了REM睡眠触发。为了更具体地确定参与介导REM睡眠对光照变化反应的区域，对顶盖前区（PT）或SC进行了保留纤维的神经毒性损伤。PT损伤减弱了REM睡眠触发，而SC损伤则没有。因此，PT的作用可能会扩大到包括对白化大鼠光刺激反应中REM睡眠的调节。这些发现提供了一个研究REM睡眠产生机制以及光对行为状态影响的范例。
