Tan J T, Korzh V, Gong Z
Department of Biological Sciences, National University of Singapore, Singapore.
Mech Dev. 1999 Sep;87(1-2):165-8. doi: 10.1016/s0925-4773(99)00121-5.
We describe a zebrafish gene, Ziro3, which is highly homologous to Xenopus and mouse iroquois3. Ziro3 expression starts during gastrulation in the dorsal axial mesoderm that develops into the notochord. Later, the expression is limited to the chordo-neural hinge in the tailbud. Ziro3 expression also occurs in the central nervous system (CNS), excluding the telencephalon. The level of Ziro3 expression differs in odd and even rhombomeres. In the midbrain-hindbrain boundary (MHB) and rhombomere 6, Ziro3 transcripts appear only after the formation of the cerebellum and otic vesicle, respectively.
我们描述了一种斑马鱼基因Ziro3，它与非洲爪蟾和小鼠的iroquois3高度同源。Ziro3的表达在原肠胚形成期开始于发育成脊索的背轴中胚层。之后，表达局限于尾芽中的脊索神经铰链。Ziro3的表达也出现在中枢神经系统（CNS）中，但不包括端脑。Ziro3的表达水平在奇数和偶数菱脑节中有所不同。在中脑-后脑边界（MHB）和菱脑节6中，Ziro3转录本分别在小脑和耳泡形成之后才出现。
