Goriely A, Diez del Corral R, Storey K G
Department of Human Anatomy and Genetics, University of Oxford, South Parks Rd., Oxford, UK.
Mech Dev. 1999 Sep;87(1-2):203-6. doi: 10.1016/s0925-4773(99)00149-5.
We have cloned c-Irx2, a chick homologue of the Xiro2 and mIrx2 genes and a new member of the Iroquois family of homeodomain-containing transcription factors. Strikingly, c-Irx2 expression reveals an early subdivision of the neural plate at late primitive streak stages which later transiently resolves to a single stripe within the developing hindbrain corresponding to rhombomere 1.
我们克隆了c-Irx2，它是Xiro2和mIrx2基因的鸡同源物，也是含同源结构域转录因子的Iroquois家族的新成员。引人注目的是，c-Irx2的表达在原条后期揭示了神经板的早期细分，随后在发育中的后脑内短暂地分解为对应于菱脑节1的单一条纹。
