Lewis R
Division of Occupational Toxicology, University of Louisville, KY 40292, USA.
Occup Med. 1999 Oct-Dec;14(4):719-42.
Polyvinyl chloride (PVC) is an important plastic resin for construction, pipe and tubing, siding, and other uses. Exposures to vinyl chloride monomer during the early years of production resulted in an important sentinel health event: the recognition of an excess of a rare liver cancer, hepatic angiosarcoma, at facilities throughout the world. Several other syndromes, including acro-osteolysis, also have been associated with PVC, but less clearly with vinyl chloride. Extensive research ranging from large-scale epidemiologic studies to biomarker research into molecular mechanisms continues to provide valuable insight into the pathogenesis of occupational cancer.
聚氯乙烯（PVC）是一种用于建筑、管道和管材、壁板及其他用途的重要塑料树脂。在生产初期接触氯乙烯单体会导致一个重要的标志性健康事件：世界各地的工厂都发现一种罕见的肝癌——肝血管肉瘤的发病率过高。其他几种综合征，包括肢端溶骨症，也与PVC有关，但与氯乙烯的关联不太明确。从大规模流行病学研究到分子机制的生物标志物研究等广泛的研究，继续为职业性癌症的发病机制提供有价值的见解。
