[Dependence of synergism of the combined effect of cisplatin and hyperthermia on the concentration of the drug].

The analysis of synergistic interaction of cisplatin of various concentrations and high temperature on Chinese hamster fibroblasts was performed using a mathematical model. To calculate the synergistic interaction some survival curves obtained after separate and simultaneous combined actions of these agents reported elsewhere have been used. A good agreement between experimental data and the mathematical model prognosis was provided. For a constant temperature, synergism was observed only within a certain range of cisplatin concentration. The highest value of synergism was shifted towards a lower concentration with a decrease in the temperature, at which the combined treatment was carried out. Possible practical utilization of this rule in radiation therapy, medical and food sterilization, and ecology are discussed.