[A mathematical description of the synergism in the simultaneous cytotoxic action of chemical agents and hyperthermia].

Applicability of mathematical model to the description and prognosis of cytotoxicity of tris(1-aziridinyl)-phosphine sulfide (thio-TEPA) and cis-diamminedichloroplatinum (cis-DDP) at various temperatures was tested for the inactivation of clone-forming ability of hamster cells and murine fibrosarcoma. The model suggests that the synergistic interaction of chemical agent and hyperthermia may result from additional lethal damages arising from the interaction of sublesions induced by both the agents. The model allows a quantitative analysis of the combined action of the used agents and predicts the maximum value of the synergistic effect and the conditions under which this effect can be achieved.