James L A, Kelsey A M, Birch J M, Varley J M
CRC Section of Molecular Genetics, Paterson Institute for Cancer Research, Manchester, UK.
Br J Cancer. 1999 Sep;81(2):300-4. doi: 10.1038/sj.bjc.6990691.
We have examined 11 cases of childhood adrenocortical tumours for copy number changes using comparative genomic hybridization (CGH). The changes seen are highly consistent between cases, and are independent of tumour type (carcinoma versus adenoma) or the presence of a germline TP53 mutation. The regions of chromosomal gain and loss identified in this study indicate the location of genes that are potentially important in the development and progression of childhood adrenocortical tumours. Finally, the copy number changes identified in childhood tumours are distinctly different to those seen in adult cases (Kjellman et al (1996) Cancer Res 56: 4219-4223), and we propose that this indicates that childhood tumours are of embryonal origin.
我们使用比较基因组杂交（CGH）技术检测了11例儿童肾上腺皮质肿瘤的拷贝数变化。各病例中观察到的变化高度一致，且与肿瘤类型（癌与腺瘤）或种系TP53突变的存在无关。本研究中确定的染色体增减区域表明了在儿童肾上腺皮质肿瘤发生和发展中可能起重要作用的基因的位置。最后，儿童肿瘤中确定的拷贝数变化与成人病例中观察到的明显不同（Kjellman等人，（1996年）《癌症研究》56:4219 - 4223），我们认为这表明儿童肿瘤起源于胚胎。
