Oke J M, Watt R A
London School of Pharmacy, University of London.
Afr J Med Med Sci. 1998 Sep-Dec;27(3-4):219-23.
Alpha-alpha-trehalose-6-phosphate, synthesized by Oke was screened for hypoglycaemic activity. Alloxan-induced diabetic albino rats and fasted-rabbits were used in the study. The inhibitory activity of trehalose-6-phosphate on trehalase was also assayed. The study shows that alpha-alpha-trehalose-6-phosphate is a glucose analogue with potent anti-hyperglcaemic activity as shown by its hypoglycaemic response in fasted rabbits. The ability of alpha-alpha-trehalose-6-phosphate to attenuate the diabetic toxicity in alloxan-induced diabetic rats confirmed its potent anti-diabetic activity. The mechanism of action of this synthesized compound may be linked with its ability to inhibit trehalase, and increase the activity of the superoxidase dimutase present in the beta-cells of the alloxan-diabetic rats and also being a glucose analogue according to Puls principle, alpha-alpha-trehalose-6-phosphate is able to influence the intermediate metabolism of carbohydrate.
奥克合成的α-α-海藻糖-6-磷酸被筛选用于检测其降血糖活性。该研究使用了四氧嘧啶诱导的糖尿病白化大鼠和禁食兔子。同时还测定了6-磷酸海藻糖对海藻糖酶的抑制活性。研究表明，α-α-海藻糖-6-磷酸是一种葡萄糖类似物，在禁食兔子中其降血糖反应显示出具有强大的抗高血糖活性。α-α-海藻糖-6-磷酸减轻四氧嘧啶诱导的糖尿病大鼠糖尿病毒性的能力证实了其强大的抗糖尿病活性。这种合成化合物的作用机制可能与其抑制海藻糖酶的能力有关，并且能增加四氧嘧啶糖尿病大鼠β细胞中超氧化物歧化酶的活性，此外，根据普尔斯原理，α-α-海藻糖-6-磷酸作为一种葡萄糖类似物，能够影响碳水化合物的中间代谢。
