Ju Jung Bong, Kim Ji Su, Choi Chang Won, Lee Hae Kyung, Oh Tae-Kyun, Kim Sei Chang
Department of Biology and Medicinal Science, Pai Chai University, Daejeon 302-735, Republic of Korea.
J Ethnopharmacol. 2008 Jan 4;115(1):110-5. doi: 10.1016/j.jep.2007.09.012. Epub 2007 Sep 21.
Hypoglycaemic and hypolipidemic properties of the ethanolic and aqueous extracts, respectively, from Chinese juniper (Juniperus chinensis L.) berries were investigated in alloxan-induced diabetic rats.
After oral administration of each extract singly or repeatedly to alloxan-induced diabetic rats, the blood glucose, glutamate-pyruvate transferase (GPT), glutamate-oxaloacetate transaminase (GOT), total cholesterol (TC) and triglyceride (TG) levels were assayed.
The blood glucose levels after a single oral administration of the ethanolic extract significantly reduced in a time-dependent manner, which is much faster and more than that of glibenclamide. The blood glucose levels of alloxan-induced diabetic rats treated with the ethanolic extract were reduced to 94, 81%, 66%, 45% and 40% at 1, 3, 5, 7 and 9h, respectively (p<0.05), while the aqueous extract had no effect at all. Repeated oral administration of the ethanolic extract also effectively reduced the GPT value to 58% of the diabetic rats, but slightly reduced the GOT value to 87% of the diabetic rats (p<0.05). On the other hand, the repeated oral administration of aqueous extract effectively reduced the GOT value to 43% of the diabetic rats, without affecting the GPT level. Effects of both extracts on the TC and TG levels were different. There was no significant difference in the TC and TG levels between diabetic control and diabetic groups when repeatedly administered orally with ethanolic extract. On the other hand, the aqueous extract brought down the TC value to 57% and the TG value to 37% of the diabetic control rats (p<0.05).
The results suggested that the ethanolic extract of Chinese juniper berries possesses a potential hypoglycaemic effect while the aqueous extract has a potential hypolipidemic effect.
研究杜松子（刺柏）乙醇提取物和水提取物分别对四氧嘧啶诱导的糖尿病大鼠的降血糖和降血脂特性。
将每种提取物单独或反复口服给予四氧嘧啶诱导的糖尿病大鼠后，测定血糖、谷丙转氨酶（GPT）、谷草转氨酶（GOT）、总胆固醇（TC）和甘油三酯（TG）水平。
单次口服乙醇提取物后，血糖水平呈时间依赖性显著降低，其降低速度比格列本脲更快且降低幅度更大。用乙醇提取物处理的四氧嘧啶诱导的糖尿病大鼠的血糖水平在1、3、5、7和9小时分别降至94%、81%、66%、45%和40%（p<0.05），而水提取物则完全没有效果。反复口服乙醇提取物也有效地将糖尿病大鼠的GPT值降低至58%，但将GOT值略微降低至糖尿病大鼠的87%（p<0.05）。另一方面，反复口服水提取物有效地将糖尿病大鼠的GOT值降低至43%，而不影响GPT水平。两种提取物对TC和TG水平的影响不同。反复口服乙醇提取物时，糖尿病对照组和糖尿病组之间的TC和TG水平没有显著差异。另一方面，水提取物使糖尿病对照大鼠的TC值降至57%，TG值降至37%（p<0.05）。
结果表明，杜松子乙醇提取物具有潜在的降血糖作用，而水提取物具有潜在的降血脂作用。
