Akindahunsi A A, Grissom F E, Adewusi S R, Afolabi O A, Torimiro S E, Oke O L
Department of Biochemistry, Federal University of Technology, Akure, Nigeria.
Afr J Med Med Sci. 1998 Sep-Dec;27(3-4):239-42.
The parameters of thyroid function were determined in Akungba and Oke-Agbe communities of Akoko area, where goiter is endemic and compared to a control population of Erinmo and Ifewara in Ijesha area, both areas being in southwestern Nigeria. The two study areas have similar physical and geological settings. However, while the main carbohydrate source of the control population are yam and/or bread-fruit, the Akoko population derives her carbohydrates mainly from cassava which could lead to increased serum thiocyanate, a goitrogen. The serum level of tetraiodothyronine (T4) was significantly (P < 0.05) higher in Ifewara (11.0) and Erinmo (11.8) compared to Akungba (7.1) and Oke-Agbe (8.8[symbol: see text]micrograms/dL). The triiodothyronine (T3) was significantly (P < 0.05) higher in Ifewara (193) than Erinmo (133) and also significantly (P < 0.05) higher in Oke-Agbe (127) compared to Akungba (107 mg/dL). Conversely, thyroid stimulating hormone (TSH) (microU/mL) level was significantly (P < 0.05) higher than values obtained from Ifewara (4.5) and Erinmo (3.3). T3/T4 ratio above 25, indicative of hypothyroidism and endemic goiter, was 14, 7, 4 and 0% from Akungba, Oke-Agbe, Ifewara and Erinmo, respectively. The results of the present study clearly explain the Akoko goiter endemia in the light of modification (s) of thyroid metablism.
在甲状腺肿流行的阿科科地区的阿昆巴和奥凯-阿贝社区测定了甲状腺功能参数，并与伊杰沙地区的埃林莫和伊费瓦拉的对照人群进行了比较，这两个地区均位于尼日利亚西南部。两个研究地区具有相似的自然和地质环境。然而，对照人群的主要碳水化合物来源是山药和/或面包果，而阿科科人群的碳水化合物主要来自木薯，这可能导致血清硫氰酸盐（一种致甲状腺肿物质）增加。与阿昆巴（7.1）和奥凯-阿贝（8.8微克/分升）相比，伊费瓦拉（11.0）和埃林莫（11.8）的血清四碘甲状腺原氨酸（T4）水平显著更高（P<0.05）。伊费瓦拉（193）的三碘甲状腺原氨酸（T3）显著高于埃林莫（133），与阿昆巴（107毫克/分升）相比，奥凯-阿贝（127）的T3也显著更高（P<0.05）。相反，促甲状腺激素（TSH）（微单位/毫升）水平显著高于伊费瓦拉（4.5）和埃林莫（3.3）。T3/T4比值高于25表明甲状腺功能减退和地方性甲状腺肿，阿昆巴、奥凯-阿贝、伊费瓦拉和埃林莫的该比值分别为14%、7%、4%和0%。本研究结果根据甲状腺代谢的改变清楚地解释了阿科科地区的甲状腺肿流行情况。
