Turle-Lorenzo N, Zouani B, Risso J J
Department of Neurochemistry, I.M.N.S.S.A., HIA St. Anne, Toulon Naval, France.
Physiol Behav. 1999 Sep;67(3):321-5. doi: 10.1016/s0031-9384(99)00068-2.
Narcosis is a neurological syndrome that reduces capacities of divers. Although this phenomenon appeared at the end of 19th century, the mechanisms are not yet elucidated. The greatest technical problem is that these studies are carried out under hyperbaric conditions. Nitrous oxide is known to be an inducer of narcosis, at atmospheric pressure. The aim of this study is to compare two narcotic environments; a normobaric narcosis under several percentages of nitrous oxide, and an hyperbaric narcosis under 0.9 MPa of Nitrox (N2O2 mixture). This comparison is realized on rats submitted to a fixed-ratio 15 test, in which they have to press a lever to get rewarded. The results show significant performances decreases: the number of pressed lever are reduced by 50% under Nitrox and by 70% under N2O. Nitrous oxide could be considered as a normobaric model of hyperbaric narcosis.
麻醉是一种会降低潜水员能力的神经综合征。尽管这种现象在19世纪末就已出现，但其机制尚未阐明。最大的技术问题在于这些研究是在高压条件下进行的。已知一氧化二氮在常压下是一种麻醉诱导剂。本研究的目的是比较两种麻醉环境：在几种不同百分比一氧化二氮下的常压麻醉，以及在0.9兆帕氮氧混合气（N2O2混合物）下的高压麻醉。这种比较是在接受固定比率15测试的大鼠身上进行的，在该测试中它们必须按压杠杆才能获得奖励。结果显示表现显著下降：在氮氧混合气下按压杠杆的次数减少了50%，在一氧化二氮下减少了70%。一氧化二氮可被视为高压麻醉的常压模型。
