Malesker M A, Boken D, Ruma T A, Vuchetich P J, Murphy P J, Smith P W
Alegent Health Immanuel Medical Center, Department of Pharmacy Practice, Creighton University, Omaha, Nebraska 68178, USA.
Am J Trop Med Hyg. 1999 Sep;61(3):428-30. doi: 10.4269/ajtmh.1999.61.428.
We report the first apparent case of a splenectomized individual who developed severe trypanosomiasis with central nervous system involvement. The patient was a 41-year-old man who participated in an east African safari. Upon his return to the United States, the patient presented with an infection with Trypanosoma brucei rhodesiense that was treated successfully with suramin and melarsoprol. The onset of symptoms, laboratory studies, and disease progression did not differ from previously reported cases in the literature. The role of the spleen in trypanosomiasis is not well understood and the few reports available describe only animal models. This report suggests that asplenia had no apparent effect on the onset of symptoms and overall severity of illness. Further studies are necessary to ultimately define the role of the spleen in trypanosomiasis.
我们报告了首例明显的脾切除个体发生伴有中枢神经系统受累的严重锥虫病病例。患者为一名41岁男性，曾参加东非狩猎旅行。回到美国后，该患者被诊断为布氏罗得西亚锥虫感染，接受苏拉明和美拉胂醇治疗后成功康复。症状的发作、实验室检查及疾病进展与文献中先前报道的病例并无差异。脾脏在锥虫病中的作用尚未完全明确，现有少数报告仅描述了动物模型。本报告表明，无脾对症状发作及疾病总体严重程度并无明显影响。有必要进行进一步研究以最终确定脾脏在锥虫病中的作用。
