Zahradka D, Vlahović K, Petranović M, Petranović D
Department of Molecular Genetics, Ruer Boskovic Institute, 10001 Zagreb, Croatia.
J Bacteriol. 1999 Oct;181(19):6179-83. doi: 10.1128/JB.181.19.6179-6183.1999.
The RuvC protein is important for DNA recombination and repair in Escherichia coli. The present work shows that a ruvC null mutation introduced into a recBC sbcBC background causes severe defects in chromosome segregation and cell division. Both defects were found to result from abortive recombination initiated by the RecA protein.
RuvC蛋白对大肠杆菌中的DNA重组和修复很重要。目前的研究表明,引入recBC sbcBC背景中的ruvC无效突变会导致染色体分离和细胞分裂出现严重缺陷。发现这两种缺陷都是由RecA蛋白引发的流产性重组导致的。