Bao S, Guttmann C R, Mugler J P, Brookeman J R, Panych L P, Kraft R A, Oshio K, Jaramillo D, Jolesz F A, Williamson D S, Mulkern R V
Department of Radiology, Brigham and Women's Hospital, Boston, MA, USA.
Magn Reson Imaging. 1999 Oct;17(8):1203-10. doi: 10.1016/s0730-725x(99)00056-9.
Lipid characterization of bone marrow in vivo with proton magnetic resonance spectroscopy was performed using Spin-Echo Planar Spectroscopic Imaging sequences. The methods are shown capable of rapidly generating two-dimensional chemical shift imaging data sets suitable for measuring lipid indices that reflect unsaturation levels among triglycerides, as demonstrated in oil phantoms and bone marrow from a healthy volunteer. The volume coverage, spatial resolution, acquisition speed, and spectral characteristics of Spin-Echo Planar Spectroscopic Imaging should make it attractive for clinical studies of diseases affecting normal lipid chemical composition.
利用自旋回波平面光谱成像序列对体内骨髓进行质子磁共振波谱脂质表征。如在油模体和一名健康志愿者的骨髓中所证实的那样，这些方法能够快速生成适用于测量反映甘油三酯不饱和水平的脂质指数的二维化学位移成像数据集。自旋回波平面光谱成像的体积覆盖范围、空间分辨率、采集速度和光谱特征使其对影响正常脂质化学成分的疾病的临床研究具有吸引力。
