Peralta C, León O S, Xaus C, Prats N, Jalil E C, Planell E S, Puig-Parellada P, Gelpí E, Roselló-Catafau J
Department of Medical Bioanalysis, Instituto de Investigaciones Biomédicas de Barcelona, CSIC-IDIBAPS, Spain.
Free Radic Res. 1999 Sep;31(3):191-6. doi: 10.1080/10715769900300741.
The effects of ozone treatment on the injury associated to hepatic ischemia-reperfusion (I/R) was evaluated. Ozone treatment (1 mg/kg daily during 10 days by rectal insufflation) is shown to be protective as it attenuated the increases in transaminases (AST, ALT) and lactate levels observed after I/R. I/R leads to a decrease in endogenous antioxidant (SOD and glutathione) and an increase in reactive oxygen species (H2O2) with respect to the control group. However, ozone treatment results in a preservation (glutathione) or increase (SOD) in antioxidant defense and maintains H2O2 at levels comparable to those in the control group. The present study reports a protective effect of ozone treatment on the injury associated to hepatic I/R. The effectiveness of ozone could be related to its action on endogenous antioxidants and prooxidants balance in favour of antioxidants, thus attenuating oxidative stress.
评估了臭氧治疗对肝脏缺血再灌注（I/R）相关损伤的影响。臭氧治疗（通过直肠注入，每天1毫克/千克，持续10天）显示出具有保护作用，因为它减轻了I/R后观察到的转氨酶（AST、ALT）和乳酸水平的升高。与对照组相比，I/R导致内源性抗氧化剂（超氧化物歧化酶和谷胱甘肽）减少，活性氧（H2O2）增加。然而，臭氧治疗可使抗氧化防御得以保留（谷胱甘肽）或增加（超氧化物歧化酶），并使H2O2维持在与对照组相当的水平。本研究报告了臭氧治疗对肝脏I/R相关损伤的保护作用。臭氧的有效性可能与其对内源性抗氧化剂和促氧化剂平衡的作用有关，有利于抗氧化剂，从而减轻氧化应激。
