Kötter I, Müller C A, Einsele H, Mohren M, Kanz L
Medizinische Universitätsklinik, Otfried-Müller-Str. 10 D-72076, Tübingen.
Z Rheumatol. 1999 Aug;58(4):185-95. doi: 10.1007/s003930050169.
We describe a patient with chronic myelogenous leukemia (CML) and a patient with hairy cell leukemia being effectively treated with alpha-interferon who developed a seropositive chronic polyarthritis formally fulfilling the ACR criteria for rheumatoid arthritis. Because of its efficacy, interferon was not discontinued, and the arthritis treated with low-dose prednisolone or NSAIDS. These are the 19th and 20th case of symmetrical polyarthritis during alpha-interferon therapy fulfilling the criteria for RA. The possible mechanisms of the relatively frequent appearance of autoimmune diseases during interferon therapy are discussed.
我们描述了一名慢性粒细胞白血病（CML）患者和一名毛细胞白血病患者，他们在接受α干扰素有效治疗期间发生了血清学阳性的慢性多关节炎，该关节炎正式符合美国风湿病学会（ACR）类风湿关节炎的标准。由于干扰素的疗效，并未停用，关节炎采用小剂量泼尼松龙或非甾体抗炎药进行治疗。这是第19例和第20例在α干扰素治疗期间出现符合类风湿关节炎标准的对称性多关节炎病例。文中讨论了干扰素治疗期间自身免疫性疾病相对频繁出现的可能机制。
