Senel Soner, Kaya Emin, Aydogdu Ismet, Erkurt M Ali, Kuku Irfan
Department of Internal Medicine Turgut Ozal Medical Center, Inonu University Faculty of Medicine, 44069 Malatya, Turkey.
Rheumatol Int. 2006 Jul;26(9):857-61. doi: 10.1007/s00296-005-0100-5. Epub 2006 Jan 11.
We report four patients with rheumatic disease (RD) and chronic myelogenous leukemia (CML). In two patients with Behcet's disease (BD) and rheumatoid arthritis (RA), CML developed after RD, in two patients with diffuse cutaneous systemic sclerosis and spondyloarthropathy, RD was diagnosed after CML. A variety of interactions have been described between hematological malignancies and RD. Nevertheless, few cases of RD have been documented associated with CML. It is unclear whether the development of CML in patients with RD and RD development after CML occurs by chance alone, is due to the underlying disease, or is facilitated by drugs. Whatever the cause is, it should be kept in mind that CML may develop in the course of RD and RD may be seen in CML patients.
我们报告了4例患有风湿性疾病（RD）和慢性粒细胞白血病（CML）的患者。在2例白塞病（BD）和类风湿关节炎（RA）患者中，CML在RD之后发生；在2例弥漫性皮肤系统性硬化症和脊柱关节病患者中，RD在CML之后被诊断出来。血液系统恶性肿瘤与RD之间已描述了多种相互作用。然而，很少有RD与CML相关的病例记录。尚不清楚RD患者中CML的发生以及CML之后RD的发生是仅仅出于偶然、是由于潜在疾病还是由药物促成。无论原因是什么，都应记住在RD病程中可能发生CML，而在CML患者中也可能出现RD。
