环境因素在胰岛素依赖型糖尿病中的作用：一个尚未解决的问题。

The role of environmental factors in insulin-dependent diabetes mellitus: an unresolved issue.

作者信息

Kraine M R, Tisch R M

机构信息

Department of Microbiology and Immunology, University of North Carolina, Chapel Hill 27599-7290, USA.

出版信息

Environ Health Perspect. 1999 Oct;107 Suppl 5(Suppl 5):777-81. doi: 10.1289/ehp.99107s5777.

DOI:10.1289/ehp.99107s5777

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1566241/

Abstract

Insulin-dependent diabetes mellitus (IDDM) is an autoimmune disease characterized by the destruction of the insulin-secreting beta cells found in the islets of Langerhans. Reduced beta-cell mass results in overt diabetes, requiring lifelong exogenous insulin administration and the possibility of numerous sequelae. Incidence and development of IDDM depend upon a variety of genetic and nongenetic factors. Environmental factors such as chemicals, diet, and infection are suspected to influence the development of disease. This review describes the work performed to date to elucidate the role of these environmental factors in IDDM.

摘要

胰岛素依赖型糖尿病（IDDM）是一种自身免疫性疾病，其特征是胰岛中分泌胰岛素的β细胞被破坏。β细胞数量减少会导致显性糖尿病，需要终身注射外源性胰岛素，并可能引发多种后遗症。IDDM的发病率和发展取决于多种遗传和非遗传因素。化学物质、饮食和感染等环境因素被怀疑会影响疾病的发展。这篇综述描述了迄今为止为阐明这些环境因素在IDDM中的作用所开展的工作。

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