Knupp-Oliveira S, Cerinic M M
Department of Pediatrics, Universidade Federal do Rio de Janeiro, Brasil.
Scand J Rheumatol. 1999;28(4):260-1. doi: 10.1080/03009749950155661.
We report the first case of a young female patient who developed a sensory-motor polyneuropathy, without any skin or internal involvement characteristic of SSc, but with a serological positivity of antitopoisomerase I antibodies. After 4 years she developed a rapid skin tightening with lung involvement, in a full blown picture of the diffuse subset of SSc. The case suggests that the peripheral nervous system deserves more attention, in particular in the earliest phase of SSc.
我们报告了首例年轻女性患者，该患者出现感觉运动性多发性神经病，无硬皮病（SSc）特征性的皮肤或内脏受累表现，但抗拓扑异构酶I抗体血清学呈阳性。4年后，她迅速出现皮肤紧绷并伴有肺部受累，呈现出弥漫型SSc的典型症状。该病例提示，外周神经系统值得更多关注，尤其是在SSc的早期阶段。
