Sato S, Ihn H, Soma Y, Shimozuma M, Shishiba T, Takehara K
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
J Rheumatol. 1993 Nov;20(11):1961-3.
We describe a case of systemic sclerosis (SSc) positive for 3 autoantibodies; anticentromere antibody, antitopoisomerase I antibody, and anti-U1RNP antibody, It is known that coexistence of 2 of these 3 antibodies is rare and the coexistence of these 3 antibodies in serum from a patient with SSc has not been reported. In addition, we examined our stock serum samples from 236 cases with SSc or related disorders for the presence of specific antinuclear antibodies and were unable to find a serum sample containing all 3 antibodies.
我们描述了一例系统性硬化症（SSc）患者，其体内三种自身抗体呈阳性，即抗着丝点抗体、抗拓扑异构酶I抗体和抗U1RNP抗体。已知这三种抗体中的两种同时存在的情况很罕见，而SSc患者血清中这三种抗体同时存在的情况尚未见报道。此外，我们检查了236例SSc或相关疾病患者的库存血清样本中特定抗核抗体的存在情况，未发现含有所有三种抗体的血清样本。
