Takeshima Y, Sanda N, Yoneda K, Inai K
Second Department of Pathology, Hiroshima University School of Medicine, Japan.
Pathol Int. 1999 Jul;49(7):676-9. doi: 10.1046/j.1440-1827.1999.00919.x.
A case of tubular seminoma in a 33-year-old man is reported. The tumor occurred in his right testis, measuring 7 x 6 x 6 cm in size. Microscopically, most of the tumor cells were arranged in solid or hollow tubular patterns. The tumor cells had round nuclei with vesicular chromatin and clear or granular cytoplasm, characteristic features of seminoma cells. A classic seminoma component and intratubular atypical germ cells occupying approximately 5% of the tumor area were noted. Immunohistochemical staining revealed that the tumor cells were diffusely placental alkaline phosphatase and vimentin positive, and focally cytokeratin positive. These findings are consistent with a tubular seminoma. The differential diagnoses are discussed.
报告了一例33岁男性的管状精原细胞瘤病例。肿瘤发生于其右侧睾丸，大小为7×6×6厘米。显微镜下，大部分肿瘤细胞呈实性或空心管状排列。肿瘤细胞具有圆形核，核染色质呈泡状，胞质清亮或呈颗粒状，这是精原细胞瘤细胞的特征性表现。可见一个典型的精原细胞瘤成分以及占肿瘤面积约5%的管内非典型生殖细胞。免疫组化染色显示肿瘤细胞弥漫性胎盘碱性磷酸酶和波形蛋白阳性，局灶性细胞角蛋白阳性。这些发现符合管状精原细胞瘤。文中讨论了鉴别诊断。
