Petersson Fredrik, Michal Michal, Grossmann Petr, Franco Marcello, Zámecník Michal, Hes Ondrej
Department of Pathology, National University Health System, Singapore 119074.
Int J Clin Exp Pathol. 2009 Nov 1;3(2):203-9.
A 30-year-old male with no previous history of neoplastic disease presented with a 5 cm large testicular tumor. Routine histopathological examination and immunohistochemical investigation showed a classical seminoma with a contiguous 8 mm large nodule. The nodule was separated from the tunica albuginea by tubuli seminiferi showing intratesticular germ cell neoplasi not otherwise specified (NOS). The nodule was composed of spindle cells with low-grade nuclear atypia, nuclear and cytoplasmic S100 protein immunoreactivity in 15% of the cells and a proliferative activity of up to 20%. No other germ cell tumor components were found. To the best of our knowledge, we herein present the first tumor of a pure classical seminoma with an associated low-grade sarcomatous component.
一名30岁男性，既往无肿瘤病史，现出现一个5厘米大的睾丸肿瘤。常规组织病理学检查和免疫组化研究显示为典型精原细胞瘤，伴有一个相邻的8毫米大结节。该结节通过显示睾丸内未另行指定的生殖细胞肿瘤（NOS）的生精小管与白膜分离。结节由具有低度核异型性的梭形细胞组成，15%的细胞有核和胞质S100蛋白免疫反应性，增殖活性高达20%。未发现其他生殖细胞肿瘤成分。据我们所知，本文首次报道了一例伴有低级别肉瘤成分的纯典型精原细胞瘤肿瘤。
