Apichartpiyakul C, Apichartpiyakul N, Urwijitaroon Y, Gray J, Natpratan C, Katayama Y, Fujii M, Hotta H
Department of Microbiology, Faculty of Medicine, Chiang Mai University, Thailand.
Jpn J Infect Dis. 1999 Jun;52(3):121-3.
The prevalence of antibodies against hepatitis C virus (HCV) and the distribution pattern of HCV subtypes were analyzed among healthy blood donors and intravenous drug users (IVDUs) in northern/northeastern Thailand. The prevalence of anti-HCV antibodies was 3.2% (26/820) among blood donors in Khon Kaen, while it was 90% (71/79) among IVDUs in Chiang Rai. HCV RNA was detected in all anti-HCV-positive sera collected from blood donors and IVDUs tested, as determined by reverse transcription-PCR analysis. Sequence analyses of amplified fragments of the HCV genome revealed that in Khon Kaen and Chiang Rai, Thailand, HCV-3a (50-60%) was the most common HCV subtype, followed by HCV-1a, HCV-1b, and subtypes of clade 6, each at 10-20%.
在泰国北部/东北部的健康献血者和静脉吸毒者（IVDUs）中，分析了丙型肝炎病毒（HCV）抗体的流行情况以及HCV亚型的分布模式。孔敬的献血者中抗-HCV抗体的流行率为3.2%（26/820），而清莱的IVDUs中该流行率为90%（71/79）。通过逆转录-聚合酶链反应分析确定，在所有检测的献血者和IVDUs的抗-HCV阳性血清中均检测到HCV RNA。对HCV基因组扩增片段的序列分析显示，在泰国的孔敬和清莱，HCV-3a（50-60%）是最常见的HCV亚型，其次是HCV-1a、HCV-1b和6型分支的亚型，各占10-20%。
