Prince M R, Anzai Y, Neimatallah M, Dong Q, Rubin J M
Department of Radiology, University of Michigan, Ann Arbor, MI 48109-0030 and Weill Medical College of Cornell University, New York, NY 10021, USA.
J Magn Reson Imaging. 1999 Sep;10(3):389-94. doi: 10.1002/(sici)1522-2586(199909)10:3<389::aid-jmri21>3.0.co;2-h.
The purpose of this study was to determine the feasibility of using an ultrasound contrast agent test bolus to determine optimum bolus timing for three-dimensional (3D) gadolinium (Gd)-enhanced magnetic resonance angiography (MRA). Small test doses of ultrasound contrast agent (0.3 ml Optison) were injected intravenously followed immediately by a 20 ml saline flush. Arrival of the contrast agent was detected by spectral Doppler ultrasound (US). This technique was implemented in patients undergoing peripheral vascular MRA and carotid MRA. Arrival of the US contrast agent test bolus was readily detected by the change in amplitude of the Doppler spectrum and by a huge increase in the audio signal amplitude. This contrast travel time measurement accurately guided bolus timing for 3D Gd MRA. Bolus timing for 3D contrast-enhanced MRA can be performed using US, thereby eliminating the problems and MR scanner time required for injecting a test bolus of Gd contrast.
本研究的目的是确定使用超声造影剂试验团注来确定三维（3D）钆（Gd）增强磁共振血管造影（MRA）的最佳团注时机的可行性。静脉注射小剂量超声造影剂（0.3 ml Optison），随后立即用20 ml生理盐水冲洗。通过频谱多普勒超声（US）检测造影剂的到达。该技术应用于接受外周血管MRA和颈动脉MRA的患者。通过多普勒频谱幅度的变化和音频信号幅度的大幅增加，很容易检测到超声造影剂试验团注的到达。这种造影剂通过时间测量准确地指导了3D Gd MRA的团注时机。3D对比增强MRA的团注时机可以使用超声来执行，从而消除了注射Gd对比剂试验团注所需的问题和磁共振扫描仪时间。
