金属β-内酰胺酶：结构与机制
Metallo-beta-lactamase: structure and mechanism.
作者信息
Wang Z, Fast W, Valentine A M, Benkovic S J
机构信息
The Pennsylvania State University, Department of Chemistry, 152 Davey Laboratory, University Park, PA 16802, USA.
出版信息
Curr Opin Chem Biol. 1999 Oct;3(5):614-22. doi: 10.1016/s1367-5931(99)00017-4.
Abstract
This past year has produced determinations of X-ray crystal structures for three metallo-beta-lactamases and the elucidation of the catalytic mechanisms for a monozinc and a dizinc enzyme. These advances shed light on how such a diverse group of enzymes are evolving to inactivate so efficiently a broad spectrum of beta-lactam antibiotics.
摘要
在过去的一年里，已确定了三种金属β-内酰胺酶的X射线晶体结构，并阐明了一种单锌酶和一种双锌酶的催化机制。这些进展揭示了如此多样的一组酶是如何进化以如此有效地使广谱β-内酰胺抗生素失活的。
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