Bienz M
Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge, CB2 2QH, UK.
Curr Opin Genet Dev. 1999 Oct;9(5):595-603. doi: 10.1016/s0959-437x(99)00016-7.
Adenomatous polyposis coli (APC) is an important tumour suppressor in the human colon. It is conserved between human and flies, and promotes, together with Axin and glycogen synthase kinase 3 (GSK3), the degradation of the Wnt-signalling effector beta-catenin. Recent experiments have shaped our understanding of how Axin and GSK3 function but the role of APC in this process remains elusive.
腺瘤性结肠息肉病蛋白（APC）是人类结肠中一种重要的肿瘤抑制因子。它在人类和果蝇之间具有保守性，并与轴抑制蛋白（Axin）和糖原合酶激酶3（GSK3）共同促进Wnt信号效应分子β-连环蛋白的降解。最近的实验使我们对Axin和GSK3的功能有了一定的认识，但APC在这一过程中的作用仍不清楚。
