血管生成开关分子，即分泌型成纤维细胞生长因子结合蛋白，是胰腺和结肠直肠癌早期阶段的一个指标。
The angiogenic switch molecule, secreted FGF-binding protein, an indicator of early stages of pancreatic and colorectal adenocarcinoma.
作者信息
Tassi Elena, Wellstein Anton
机构信息
Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA.
出版信息
Semin Oncol. 2006 Dec;33(6 Suppl 11):S50-6. doi: 10.1053/j.seminoncol.2006.10.014.
Abstract
Tumor angiogenesis has been related to the initiation as well as progression toward more aggressive behavior of human tumors. We will discuss genetic events underlying the initiation and progression of colorectal and pancreatic adenocarcinoma with a particular focus on the modulation of angiogenesis. A secreted fibroblast growth factor (FGF) binding protein (FGF-BP), which is an extracellular chaperone molecule for FGFs, has been shown to enhance FGF-mediated biochemical and biologic events and to be a crucial rate-limiting factor for tumor-dependent angiogenesis. Histochemical and in situ hybridization studies with archival samples show that FGF-BP is induced early during the initiation of colorectal and pancreatic adenocarcinoma. We will discuss the potential of this secreted protein as a serum marker to identify at-risk subjects.
摘要
肿瘤血管生成与人类肿瘤的起始以及向更具侵袭性的行为进展有关。我们将讨论结直肠癌和胰腺腺癌起始和进展背后的遗传事件，特别关注血管生成的调节。一种分泌型成纤维细胞生长因子（FGF）结合蛋白（FGF-BP），它是FGFs的细胞外伴侣分子，已被证明可增强FGF介导的生化和生物学事件，并且是肿瘤依赖性血管生成的关键限速因子。对存档样本的组织化学和原位杂交研究表明，FGF-BP在结直肠癌和胰腺腺癌起始早期被诱导。我们将讨论这种分泌蛋白作为血清标志物用于识别高危人群的潜力。
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本文引用的文献
1
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Cancer Res. 2006 Jan 15;66(2):1191-8. doi: 10.1158/0008-5472.CAN-05-2926.
2
Role of fibroblast growth factor-binding protein in the pathogenesis of HIV-associated hemolytic uremic syndrome.成纤维细胞生长因子结合蛋白在HIV相关溶血尿毒综合征发病机制中的作用
Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R105-13. doi: 10.1152/ajpregu.00492.2005.
3
Identification of the fibroblast growth factor (FGF)-interacting domain in a secreted FGF-binding protein by phage display.通过噬菌体展示鉴定分泌型成纤维细胞生长因子（FGF）结合蛋白中的FGF相互作用结构域。
J Biol Chem. 2006 Jan 13;281(2):1137-44. doi: 10.1074/jbc.M510754200. Epub 2005 Oct 27.
4
Colorectal cancer and antiangiogenic therapy: what can be expected in clinical practice?结直肠癌与抗血管生成治疗：临床实践中可期待什么？
Crit Rev Oncol Hematol. 2005 Jul;55(1):67-81. doi: 10.1016/j.critrevonc.2005.03.005.
5
Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis.血管生成中的成纤维细胞生长因子/成纤维细胞生长因子受体系统
Cytokine Growth Factor Rev. 2005 Apr;16(2):159-78. doi: 10.1016/j.cytogfr.2005.01.004. Epub 2005 Feb 2.
6
Structural basis for fibroblast growth factor receptor activation.成纤维细胞生长因子受体激活的结构基础。
Cytokine Growth Factor Rev. 2005 Apr;16(2):107-37. doi: 10.1016/j.cytogfr.2005.01.008.
7
Vascular leakage in chick embryos after expression of a secreted binding protein for fibroblast growth factors.
Lab Invest. 2005 Jun;85(6):747-55. doi: 10.1038/labinvest.3700269.
8
Cancer statistics, 2005.2005年癌症统计数据。
CA Cancer J Clin. 2005 Jan-Feb;55(1):10-30. doi: 10.3322/canjclin.55.1.10.
9
Evolution of the Fgf and Fgfr gene families.Fgf和Fgfr基因家族的进化。
Trends Genet. 2004 Nov;20(11):563-9. doi: 10.1016/j.tig.2004.08.007.
10
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Expert Opin Investig Drugs. 2004 Jun;13(6):631-41. doi: 10.1517/13543784.13.6.631.
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