Wu X, Xu L, Cai J
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, PR China.
Bioorg Med Chem Lett. 1999 Sep 20;9(18):2635-8. doi: 10.1016/s0960-894x(99)00457-6.
Cycloalkanin was accessible by a practical and efficient asymmetric synthesis. The chiral center of the target is introduced via an asymmetric C-arylation of chiral aldehyde in high de. The synthesized cycloalkanin was shown to be significantly active against P388 cell line as assayed by in vitro MIT method.
环烷宁可通过实用且高效的不对称合成方法获得。目标化合物的手性中心通过手性醛的不对称碳芳基化反应以高对映体过量引入。通过体外MTT法测定，合成的环烷宁对P388细胞系显示出显著活性。
