新型细胞毒性氮杂萘醌吡咯并稠合衍生物的合成与生物评价。
Synthesis and biological evaluation of new cytotoxic azanaphthoquinone pyrrolo-annelated derivatives.
机构信息
Department of Drug and Natural Product Synthesis, University of Vienna, Austria.
出版信息
Bioorg Med Chem Lett. 2010 Jul 1;20(13):3950-2. doi: 10.1016/j.bmcl.2010.05.003. Epub 2010 May 7.
PMID:20537894
Abstract
A series of azanaphthoquinone pyrrolo-annelated derivatives attached to basic side chains have been synthesized. The antiproliferative activities of all compounds were evaluated on at least four different cell lines. The effects on cell cycle and intercalation were investigated.
摘要
已经合成了一系列连接碱性侧链的薁萘醌吡咯并并环化衍生物。所有化合物的抗增殖活性至少在四种不同的细胞系上进行了评估。研究了对细胞周期和嵌入的影响。
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