组织蛋白酶P，一种小鼠胎盘中的新型蛋白酶。
Cathepsin P, a novel protease in mouse placenta.
作者信息
Sol-Church K, Frenck J, Troeber D, Mason R W
机构信息
Laboratory of Enzymology, Department of Research, Alfred I. duPont Hospital for Children, Wilmington, DE 19899, USA.
出版信息
Biochem J. 1999 Oct 15;343 Pt 2(Pt 2):307-9.
Abstract
The complete cDNA nucleotide sequence of a novel cathepsin derived from mouse placenta, termed cathepsin P, was determined. mRNA for cathepsin P was expressed in placenta and at lower levels in visceral yolk sac, but could not be detected in a range of adult tissues. The expression pattern of this protease indicates that it probably plays an important role during implantation and fetal development.
摘要
确定了一种源自小鼠胎盘的新型组织蛋白酶（称为组织蛋白酶P）的完整cDNA核苷酸序列。组织蛋白酶P的mRNA在胎盘中表达，在内脏卵黄囊中表达水平较低，但在一系列成年组织中未检测到。这种蛋白酶的表达模式表明它可能在植入和胎儿发育过程中起重要作用。
相似文献
1
Cathepsin P, a novel protease in mouse placenta.组织蛋白酶P，一种小鼠胎盘中的新型蛋白酶。
Biochem J. 1999 Oct 15;343 Pt 2(Pt 2):307-9.
2
Cathepsin Q, a novel lysosomal cysteine protease highly expressed in placenta.组织蛋白酶Q，一种在胎盘中高度表达的新型溶酶体半胱氨酸蛋白酶。
Biochem Biophys Res Commun. 2000 Jan 27;267(3):791-5. doi: 10.1006/bbrc.1999.2051.
3
Mouse cathepsin M, a placenta-specific lysosomal cysteine protease related to cathepsins L and P.
Biochim Biophys Acta. 2000 Apr 25;1491(1-3):289-94. doi: 10.1016/s0167-4781(00)00030-0.
4
Expression of cysteine proteases in extraembryonic tissues during mouse embryogenesis.小鼠胚胎发育过程中半胱氨酸蛋白酶在胚外组织中的表达。
Arch Biochem Biophys. 1999 Dec 15;372(2):375-81. doi: 10.1006/abbi.1999.1520.
5
Cloning and expression of a rat placental cDNA encoding a novel cathepsin L-related protein.编码一种新型组织蛋白酶L相关蛋白的大鼠胎盘cDNA的克隆与表达
Mol Reprod Dev. 1995 Feb;40(2):146-56. doi: 10.1002/mrd.1080400203.
6
Evolution of placentally expressed cathepsins.胎盘表达的组织蛋白酶的进化。
Biochem Biophys Res Commun. 2002 Apr 26;293(1):23-9. doi: 10.1016/S0006-291X(02)00167-5.
7
Cloning and complete coding sequence of a novel human cathepsin expressed in giant cells of osteoclastomas.
J Bone Miner Res. 1995 Aug;10(8):1197-202. doi: 10.1002/jbmr.5650100809.
8
Cathepsin-6, a novel cysteine proteinase showing homology with and co-localized expression with cathepsin J/P in the labyrinthine layer of mouse placenta.组织蛋白酶-6，一种新型半胱氨酸蛋白酶，与组织蛋白酶J/P具有同源性且在小鼠胎盘迷路层中与组织蛋白酶J/P共定位表达。
Biochem J. 2000 Aug 1;349 Pt 3(Pt 3):689-92. doi: 10.1042/bj3490689.
9
Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts.组织蛋白酶K在人破骨细胞中大量表达，而组织蛋白酶B、L或S则不然。
J Biol Chem. 1996 May 24;271(21):12511-6. doi: 10.1074/jbc.271.21.12511.
10
Molecular cloning and sequencing of two cDNAs encoding cathepsin L-related cysteine proteinases in the nervous system and in the stomach of the Norway lobster (Nephrops norvegicus).挪威龙虾（Nephrops norvegicus）神经系统和胃中两种编码组织蛋白酶L相关半胱氨酸蛋白酶的cDNA的分子克隆与测序
Comp Biochem Physiol B Biochem Mol Biol. 1995 Jul;111(3):353-9. doi: 10.1016/0305-0491(95)00001-o.
引用本文的文献
1
Protein processing by the placental protease, cathepsin P.胎盘蛋白酶组织蛋白酶P对蛋白质的加工处理
Mol Hum Reprod. 2009 Jul;15(7):433-42. doi: 10.1093/molehr/gap029. Epub 2009 Apr 3.
2
Expression of cathepsin P mRNA, protein and activity in the rat choriocarcinoma cell line, Rcho-1, during giant cell transformation.组织蛋白酶 P mRNA、蛋白及其活性在大鼠绒癌细胞系 Rcho-1 中的表达与巨细胞转化。
Placenta. 2007 Aug-Sep;28(8-9):912-9. doi: 10.1016/j.placenta.2006.11.007. Epub 2007 Jan 10.
3
Expression and characterization of cathepsin P.组织蛋白酶P的表达与特性分析
Biochem J. 2004 Mar 1;378(Pt 2):657-63. doi: 10.1042/BJ20031548.
4
Cathepsin-6, a novel cysteine proteinase showing homology with and co-localized expression with cathepsin J/P in the labyrinthine layer of mouse placenta.组织蛋白酶-6，一种新型半胱氨酸蛋白酶，与组织蛋白酶J/P具有同源性且在小鼠胎盘迷路层中与组织蛋白酶J/P共定位表达。
Biochem J. 2000 Aug 1;349 Pt 3(Pt 3):689-92. doi: 10.1042/bj3490689.
本文引用的文献
1
Molecular cloning and structural and functional characterization of human cathepsin F, a new cysteine proteinase of the papain family with a long propeptide domain.人组织蛋白酶F的分子克隆及其结构与功能特性，木瓜蛋白酶家族中一种具有长前肽结构域的新型半胱氨酸蛋白酶。
J Biol Chem. 1999 May 14;274(20):13800-9. doi: 10.1074/jbc.274.20.13800.
2
Impaired invariant chain degradation and antigen presentation and diminished collagen-induced arthritis in cathepsin S null mice.组织蛋白酶S基因敲除小鼠中恒定链降解和抗原呈递受损，胶原诱导的关节炎减轻。
Immunity. 1999 Feb;10(2):207-17. doi: 10.1016/s1074-7613(00)80021-7.
3
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus.组织蛋白酶L：在Ii降解及胸腺中CD4 T细胞选择过程中起关键作用。
Science. 1998 Apr 17;280(5362):450-3. doi: 10.1126/science.280.5362.450.
4
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation.组织蛋白酶B和D对于主要组织相容性复合体II类介导的抗原呈递并非必需。
Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4516-21. doi: 10.1073/pnas.95.8.4516.
5
The expression and function of cystatin C and cathepsin B and cathepsin L during mouse embryo implantation and placentation.胱抑素C、组织蛋白酶B和组织蛋白酶L在小鼠胚胎着床和胎盘形成过程中的表达及功能
Development. 1997 Sep;124(17):3415-25. doi: 10.1242/dev.124.17.3415.
6
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.空位BLAST和位置特异性迭代BLAST：新一代蛋白质数据库搜索程序。
Nucleic Acids Res. 1997 Sep 1;25(17):3389-402. doi: 10.1093/nar/25.17.3389.
7
Lysosomal metabolism of proteins.蛋白质的溶酶体代谢
Subcell Biochem. 1996;27:159-90. doi: 10.1007/978-1-4615-5833-0_6.
8
Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency.致密性骨发育不全症，一种由组织蛋白酶K缺乏引起的溶酶体疾病。
Science. 1996 Aug 30;273(5279):1236-8. doi: 10.1126/science.273.5279.1236.
9
In vitro embryotoxicity of the cysteine proteinase inhibitors benzyloxycarbonyl-phenylalanine-alanine-diazomethane (Z-Phe-Ala-CHN2) and benzyloxycarbonyl-phenylalanine-phenylalanine-diazomethane (Z-Phe-Phe-CHN2).半胱氨酸蛋白酶抑制剂苄氧羰基-苯丙氨酸-丙氨酸-重氮甲烷（Z-Phe-Ala-CHN2）和苄氧羰基-苯丙氨酸-苯丙氨酸-重氮甲烷（Z-Phe-Phe-CHN2）的体外胚胎毒性
Teratology. 1994 Sep;50(3):214-28. doi: 10.1002/tera.1420500307.
10
Cloning and expression of a rat placental cDNA encoding a novel cathepsin L-related protein.编码一种新型组织蛋白酶L相关蛋白的大鼠胎盘cDNA的克隆与表达
Mol Reprod Dev. 1995 Feb;40(2):146-56. doi: 10.1002/mrd.1080400203.
Zotero 插件