组织蛋白酶Q，一种在胎盘中高度表达的新型溶酶体半胱氨酸蛋白酶。

Cathepsin Q, a novel lysosomal cysteine protease highly expressed in placenta.

作者信息

Sol-Church K, Frenck J, Mason R W

机构信息

Laboratory of Enzymology, Alfred I. duPont Hospital for Children, Wilmington, Delaware, 19899, USA.

出版信息

Biochem Biophys Res Commun. 2000 Jan 27;267(3):791-5. doi: 10.1006/bbrc.1999.2051.

DOI:10.1006/bbrc.1999.2051

PMID:10673370

Abstract

The complete nucleotide sequence of a novel cathepsin cDNA derived from rat placenta was determined and is termed cathepsin Q. The predicted protein of 343 amino acid is a member of the family C1A protease related to cathepsin L. Rat cathepsin Q and its mouse counterpart were found highly expressed in placenta, whereas no detectable levels were found in lung, spleen, heart, brain, kidney, thymus, testicle, liver, or embryonic tissues. It is predicted that cathepsin Q will differ in catalytic specificity to another placental-specific protease, cathepsin P, indicating that these enzymes will have unique proteolytic functions in extra-embryonic tissues.

摘要

确定了一种源自大鼠胎盘的新型组织蛋白酶cDNA的完整核苷酸序列，将其命名为组织蛋白酶Q。预测的由343个氨基酸组成的蛋白质是与组织蛋白酶L相关的C1A蛋白酶家族的成员。发现大鼠组织蛋白酶Q及其小鼠对应物在胎盘中高度表达，而在肺、脾、心、脑、肾、胸腺、睾丸、肝脏或胚胎组织中未检测到表达水平。据预测，组织蛋白酶Q在催化特异性上与另一种胎盘特异性蛋白酶组织蛋白酶P不同，这表明这些酶在胚外组织中将具有独特的蛋白水解功能。