Spasov A A, Lobzov M S, Sanzharovskaia N K, Kozhevnikova E V, Kuzubova E A
Volgograd State Medical Academy, Russia.
Eksp Klin Farmakol. 1999 Jul-Aug;62(4):65-6.
Experiments on guinea pigs demonstrated that preliminary injection of polycatan (standardized magnesium solution containing the mineral bischofite) into the parotid region by means of electrophoresis reduces the ototoxic effect of the aminoglycoside antibiotic kanamycin. Polycatan prevents kanamycin-induced degenerative changes of the hair cells found in the labyrinth of the internal ear and improves the local blood flow.
对豚鼠的实验表明，通过电泳法在腮腺区域预先注射聚卡坦（一种含有水氯镁石矿物质的标准化镁溶液）可降低氨基糖苷类抗生素卡那霉素的耳毒性作用。聚卡坦可防止卡那霉素引起的内耳迷路中毛细胞的退行性变化，并改善局部血流。
