Van Vactor D, Lorenz L J
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Cell Mol Life Sci. 1999 Aug 30;55(11):1355-7. doi: 10.1007/s000180050375.
The mechanisms that generate the immense complexity of synaptic connections within the developing nervous system have fascinated biologists for decades. Analysis of nervous system development in simple systems, such as insects, has made a major contribution to our understanding of the cellular and molecular mechanisms that control the formation of axon pathways and precise connections. This enterprise has a long, interesting, and somewhat controversial history. This collection of reviews on axon guidance in insects provides a brief update to integrate current molecular and developmental insights in a number of areas from initial axon pathfinding to the recognition of synaptic partners.
数十年来，发育中的神经系统内产生巨大复杂性突触连接的机制一直吸引着生物学家。对诸如昆虫等简单系统中神经系统发育的分析，为我们理解控制轴突通路形成和精确连接的细胞及分子机制做出了重大贡献。这项事业有着漫长、有趣且颇具争议的历史。这本关于昆虫轴突导向的综述文集提供了简要的更新内容，以整合从轴突初始路径寻找至突触伙伴识别等多个领域当前的分子和发育见解。
