Salisbury J L, Whitehead C M, Lingle W L, Barrett S L
Tumor Biology Program, Mayo Clinic Foundation, Rochester, MN 55905, USA.
Biol Cell. 1999 Jul;91(6):451-60.
The centrosome functions as the major microtubule organizing center (MTOC) of the cell and as such it determines the number, polarity, and organization of interphase and mitotic microtubules. Cytoplasmic organization, cell polarity and the equal partition of chromosomes into daughter cells at the time of cell division are all dependent on the normal function of the centrosome and on its orderly duplication, once and only once, in each cell cycle. Malignant tumor cells show characteristic defects in cell and tissue architecture and in chromosome number that can be attributed to inappropriate centrosome behavior during tumor progression. In this review, we will summarize recent observations linking centrosome defects to disruption of normal cell and tissue organization and to chromosomal instability found in malignant tumors.
中心体作为细胞主要的微管组织中心（MTOC），决定了间期和有丝分裂期微管的数量、极性和组织方式。细胞质组织、细胞极性以及细胞分裂时染色体向子细胞的均等分配均依赖于中心体的正常功能及其在每个细胞周期中仅一次的有序复制。恶性肿瘤细胞在细胞和组织结构以及染色体数目上表现出特征性缺陷，这些缺陷可归因于肿瘤进展过程中中心体的异常行为。在本综述中，我们将总结最近的观察结果，这些结果将中心体缺陷与正常细胞和组织结构的破坏以及恶性肿瘤中发现的染色体不稳定性联系起来。
