Möller G
Department of Immunology, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
Scand J Immunol. 1999 Oct;50(4):341-7. doi: 10.1046/j.1365-3083.1999.00605.x.
The Toll genes code for activation receptors for innate microbial defence in insects and have recently been found to code for the Lps receptor in murine B lymphocytes. In this study, I will present evidence to show that this family of receptors are responsible for induction of specific thymus-independent immune responses in mice. T cells do not possess these pattern-recognizing receptors, but they possess structures capable of delivering activation signals to these receptors on B cells.
Toll基因编码昆虫先天性微生物防御的激活受体，最近发现它也编码小鼠B淋巴细胞中的Lps受体。在本研究中，我将提供证据表明，这一受体家族负责诱导小鼠特定的非胸腺依赖性免疫反应。T细胞不具备这些模式识别受体，但它们拥有能够向B细胞上的这些受体传递激活信号的结构。
