Halloran M E, Longini I M, Struchiner C J
Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA.
Epidemiol Rev. 1999;21(1):73-88. doi: 10.1093/oxfordjournals.epirev.a017990.
There are many different effects to consider when evaluating vaccines in the field. In this review, we have covered some of the various measures and issues related to study design and interpretation of the different measures. We emphasize that in designing and understanding vaccine studies, it is necessary to be specific about what the effect of interest is and about the assumptions underlying the interpretation of the results. Halloran et al. (81) present design, analysis, and interpretation of vaccine studies in more detail.
在实地评估疫苗时，有许多不同的效应需要考虑。在本综述中，我们涵盖了一些与研究设计以及不同测量方法的解读相关的各种措施和问题。我们强调，在设计和理解疫苗研究时，必须明确所关注的效应是什么，以及结果解读所依据的假设是什么。哈洛伦等人（81）更详细地介绍了疫苗研究的设计、分析和解读。
