El-Hazmi M A, Lehmann H
Hemoglobin. 1976;1(1):59-74. doi: 10.3109/03630267609031022.
On a field trip toSaudi Arabia (M.A.F.E.H.) in which the relationship between alpha-thalassemia and iron deficiency was studied, a fast moving hemoglobin variant was noted in a 30 year old Saudi Arabian woman. Analysis of the hemoglobin variant showed that the amino acid substitution was beta120 Lys replaced by Asn. This variant had not been described previously and has been named Hb Riyadh. There was also present an alpha-thalassemia and details are given of the imbalance of globin chain synthesis. It was possible to improve considerably the balance in vitro by the addition of hemin.
在一次前往沙特阿拉伯（M.A.F.E.H.）的实地考察中，研究了α地中海贫血与缺铁之间的关系，在此过程中，一名30岁的沙特阿拉伯女性被发现有一种快速移动的血红蛋白变异体。对该血红蛋白变异体的分析表明，氨基酸替代为β120位的赖氨酸被天冬酰胺取代。这种变异体此前未被描述过，已被命名为Hb利雅得。同时还存在α地中海贫血，并给出了珠蛋白链合成失衡的详细情况。通过添加血红素，有可能在体外显著改善这种平衡。
