Shuto T, Hirohashi K, Kubo S, Tanaka H, Hamba H, Mikami S, Ikebe T, Kinoshita H
Second Department of Surgery, Osaka City University Medical School, Japan.
Hepatogastroenterology. 1999 Jul-Aug;46(28):2545-6.
Second hepatic resections (SHR) were performed in 2 patients with recurrent hepatocellular carcinoma (HCC) with hepatitis C virus (HCV) more than 10 years after initial curative resections. Appearance on imaging studies of the late recurrences thought to be multicentric primary tumors, was preceded by fluctuating laboratory abnormalities such as increased alanine aminotransferase activity (ALT), increased serum alpha-fetoprotein (AFP), and decreased platelet counts by as long as 2 years. Therefore, serial changes of blood tests after resection of HCC with HCV might be useful predictors of late multicentric recurrence.
对2例复发性肝细胞癌（HCC）患者进行了二次肝切除术（SHR），这些患者在首次根治性切除术后10年以上感染丙型肝炎病毒（HCV）。晚期复发在影像学检查中表现为多中心原发性肿瘤，在此之前长达2年出现波动的实验室异常，如丙氨酸转氨酶活性（ALT）升高、血清甲胎蛋白（AFP）升高和血小板计数降低。因此，HCV相关HCC切除术后血液检查的系列变化可能是晚期多中心复发的有用预测指标。
