血清鸟氨酸氨基甲酰转移酶与丙氨酸氨基转移酶的比值作为肝细胞癌的有效指标。
Ratio of serum ornithine carbamoyltransferase to alanine aminotransferase as a potent indicator for hepatocellular carcinoma.
作者信息
Murayama Hiroshi, Fukuda Yoshihiro, Tsunekawa Shoji, Ikemoto Masaki, Nagata Atsuo
机构信息
Research and Development Section, Diagnostics Department, YAMASA Corporation, 10-1 Araoi-cho 2-Chome, Choshi, Chiba, 288-0056, Japan.
出版信息
Clin Biochem. 2007 Sep;40(13-14):1077-80. doi: 10.1016/j.clinbiochem.2007.05.001. Epub 2007 May 24.
OBJECTIVES
To evaluate the clinical advantage of the ratio of serum ornithine carbamoyltransferase (OCT) to alanine aminotransferase (ALT) in the diagnosis of hepatocellular carcinoma (HCC).
DESIGN AND METHODS
Serum levels of hepatic enzyme markers and their combinations were evaluated and compared with those of two other markers for HCC.
RESULTS
OCT/ALT was significantly higher in case of HCC than chronic hepatitis or liver cirrhosis. Its sensitivity (64.3%) was higher than those of alpha-fetoprotein and PIVKA-II (21.4% and 42.9%, respectively). Fluctuations of OCT/ALT before and after treatment were similar to those of alpha-fetoprotein.
CONCLUSIONS
OCT/ALT is a potent indicator for the diagnosis and the prognosis of HCC.
目的
评估血清鸟氨酸氨基甲酰转移酶（OCT）与丙氨酸氨基转移酶（ALT）的比值在肝细胞癌（HCC）诊断中的临床优势。
设计与方法
评估并比较了肝酶标志物的血清水平及其组合与另外两种HCC标志物的血清水平。
结果
HCC患者的OCT/ALT显著高于慢性肝炎或肝硬化患者。其敏感性（64.3%）高于甲胎蛋白和异常凝血酶原（分别为21.4%和42.9%）。治疗前后OCT/ALT的波动与甲胎蛋白相似。
结论
OCT/ALT是HCC诊断和预后的有力指标。
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