Kosakamoto H, Okada S, Ueno H, Okusaka T, Ikeda M, Tanaka N, Yoshimori M, Matsuno Y
Hepatobiliary and Pancreatic Oncology Division, National Cancer Center Hospital, Tokyo, Japan.
Hepatogastroenterology. 1999 Jul-Aug;46(28):2621-4.
We present a case of pancreatic cancer demonstrating symptomatic improvement with systemic chemotherapy using 5-fluorouracil and cisplatin (FP therapy). A 43 year-old man had pancreatic cancer with para-aortic lymph node metastases. He received FP therapy and achieved a partial response. After the initiation of chemotherapy, his symptoms such as severe pain and fatigue improved remarkably. Serum interleukin-6 levels correlated with these symptoms; the level was high before chemotherapy, but the levels were decreased during the courses of FP therapy. It is important to achieve symptomatic improvement in patients with pancreatic cancer, and serum interleukin-6 levels may be useful to evaluate a symptomatic response to chemotherapy.
我们报告一例胰腺癌患者，其采用5-氟尿嘧啶和顺铂的全身化疗（FP疗法）后症状得到改善。一名43岁男性患有胰腺癌并伴有主动脉旁淋巴结转移。他接受了FP疗法并获得部分缓解。化疗开始后，他的严重疼痛和疲劳等症状明显改善。血清白细胞介素-6水平与这些症状相关；化疗前该水平较高，但在FP治疗过程中水平下降。胰腺癌患者实现症状改善很重要，血清白细胞介素-6水平可能有助于评估化疗的症状反应。
