Meera S, Rao A V, D'Souza V, Rao S B
Department of Biochemistry, Kasturba Medical College, Mangalore, India.
Indian J Exp Biol. 1999 Jul;37(7):729-30.
Blood erythrocytes of 25 confirrhed malarial patients infested with P. vivax were analyzed for peroxidation and hemolysis and results compared with 10 uninfected normal control samples. Results indicated significant increase in peroxide formation measured as malondialdehyde, both in presence and absence of H2O2, in parasite infested erythrocytes. These changes induced hemolysis of infected erythrocytes which was increased manifold in presence of H2O2 and could probably be the reason for extensive anemia reported in malaria.
对25名确诊感染间日疟原虫的疟疾患者的血液红细胞进行了过氧化和溶血分析，并将结果与10个未感染的正常对照样本进行了比较。结果表明，无论有无过氧化氢，在受寄生虫感染的红细胞中，以丙二醛衡量的过氧化物形成均显著增加。这些变化导致受感染红细胞发生溶血，在有过氧化氢存在的情况下溶血增加了许多倍，这可能是疟疾中报道的广泛贫血的原因。
