Bessho K, Carnes D L, Cavin R, Chen H Y, Ong J L
Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kyoto University, Japan.
Clin Oral Implants Res. 1999 Jun;10(3):212-8. doi: 10.1034/j.1600-0501.1999.100304.x.
The objective of this study was to evaluate the effect of bone morphogenetic protein (BMP) on the bond strength of titanium (Ti) implants at the bone-implant interface. Thirty-six Brånemark screw implants (3.75 mm diameter by 15 mm long) were implanted for 3 and 12 weeks. At 3 weeks after implantation, the mean reverse torque value for implants stimulated with BMP delivered using an atelopeptide type-I collagen carrier (74.2 +/- 5.2 N cm) was observed to be statistically greater (P < 0.000016) than the mean reverse torque value for control Ti implants (32.8 +/- 1.1 N cm). Similarly, at 12 weeks after implantation, the mean reverse torque value for implants stimulated with BMP (89.2 +/- 2.7 N cm) was statistically greater (P < 0.0042) than the mean reverse torque value for control Ti implants (75.8 +/- 2.4 N cm). In addition, histomorphometric evaluations indicated more bone contact with the BMP stimulated implant surfaces compared to the controls after 3 weeks implantation. It was concluded from this study that the use of BMP-atelopeptide type-I collagen mixture is an effective means of obtaining greater bond strength at the bone implant interface within a shorter time period than Ti implants without BMP.
本研究的目的是评估骨形态发生蛋白（BMP）对钛（Ti）种植体在骨-种植体界面结合强度的影响。植入36枚Brånemark螺钉种植体（直径3.75 mm，长15 mm），分别放置3周和12周。植入后3周，观察到使用I型胶原去端肽载体递送BMP刺激的种植体的平均反向扭矩值（74.2±5.2 N·cm）在统计学上显著高于对照Ti种植体的平均反向扭矩值（32.8±1.1 N·cm）（P<0.000016）。同样，植入后12周，BMP刺激的种植体的平均反向扭矩值（89.2±2.7 N·cm）在统计学上显著高于对照Ti种植体的平均反向扭矩值（75.8±2.4 N·cm）（P<0.0042）。此外，组织形态计量学评估表明，植入3周后，与对照组相比，BMP刺激的种植体表面有更多的骨接触。本研究得出的结论是，与未使用BMP的Ti种植体相比，使用BMP-I型胶原去端肽混合物是在更短时间内在骨-种植体界面获得更大结合强度 的有效方法。
