Sheikh Zeeshan, Javaid Mohammad Ahmad, Hamdan Nader, Hashmi Raheel
Faculty of Dentistry, University of Toronto, 150 College Street, Toronto, ON M5S 3E2, Canada.
Division of Periodontics, Faculty of Dentistry, the Nobel Biocare Oral Health Centre, the University of British Columbia, 2151 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada.
Materials (Basel). 2015 Apr 15;8(4):1778-1816. doi: 10.3390/ma8041778.
Trauma and disease frequently result in fractures or critical sized bone defects and their management at times necessitates bone grafting. The process of bone healing or regeneration involves intricate network of molecules including bone morphogenetic proteins (BMPs). BMPs belong to a larger superfamily of proteins and are very promising and intensively studied for in the enhancement of bone healing. More than 20 types of BMPs have been identified but only a subset of BMPs can induce bone formation. Many research groups have shown that BMPs can induce differentiation of mesenchymal stem cells and stem cells into osteogenic cells which are capable of producing bone. This review introduces BMPs and discusses current advances in preclinical and clinical application of utilizing various biomaterial carriers for local delivery of BMPs to enhance bone regeneration.
创伤和疾病常常导致骨折或临界尺寸的骨缺损，对其进行治疗有时需要进行骨移植。骨愈合或再生过程涉及复杂的分子网络，其中包括骨形态发生蛋白（BMPs）。BMPs属于一个更大的蛋白质超家族，在促进骨愈合方面具有很大潜力且受到广泛研究。已鉴定出20多种BMPs，但只有一部分BMPs能够诱导骨形成。许多研究小组表明，BMPs可诱导间充质干细胞和干细胞分化为能够产生骨的成骨细胞。本综述介绍了BMPs，并讨论了利用各种生物材料载体局部递送BMPs以促进骨再生的临床前和临床应用的当前进展。
