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根部牙本质龋的分子发病机制

Molecular pathogenesis of root dentin caries.

作者信息

Dung T Z, Liu A H

机构信息

Division of Periodontology, Yang-Ming University, Taipai, Taiwan.

出版信息

Oral Dis. 1999 Apr;5(2):92-9. doi: 10.1111/j.1601-0825.1999.tb00071.x.

DOI:10.1111/j.1601-0825.1999.tb00071.x
PMID:10522203
Abstract

Human dentin has a higher content of organic matrix and more non-ideal hydroxyapatite than human enamel. Ultrastructural studies indicate that root caries involves both mineral dissolution and breakdown of the organic matrix. Factors involved in the root caries process seem more complicated than those in enamel caries. Moreover, the distinct roles of acids and enzymes and the sequence of events in the root caries process are not well-understood. Although Streptococcus mutans and Actinomyces viscosus are considered to be major pathogenic micro-organisms of root caries, their roles in degradation of the organic matrix components of root dentin need clarification. The purpose of this paper is to review the basic composition of root dentin and the roles of acids and both endogenous and bacterial enzymes in the root caries process.

摘要

与人类牙釉质相比,人类牙本质具有更高含量的有机基质和更多不理想的羟基磷灰石。超微结构研究表明,根龋涉及矿物质溶解和有机基质的分解。参与根龋过程的因素似乎比釉质龋中的因素更为复杂。此外,酸和酶的独特作用以及根龋过程中事件的顺序尚未得到充分理解。虽然变形链球菌和粘性放线菌被认为是根龋的主要致病微生物,但它们在根牙本质有机基质成分降解中的作用需要阐明。本文的目的是综述根牙本质的基本组成以及酸、内源性酶和细菌酶在根龋过程中的作用。

相似文献

1
Molecular pathogenesis of root dentin caries.根部牙本质龋的分子发病机制
Oral Dis. 1999 Apr;5(2):92-9. doi: 10.1111/j.1601-0825.1999.tb00071.x.
2
Ecological Hypothesis of Dentin and Root Caries.牙本质和根龋的生态学假说
Caries Res. 2016;50(4):422-31. doi: 10.1159/000447309. Epub 2016 Jul 27.
3
Effects of mutans streptococci, Actinomyces species and Porphyromonas gingivalis on collagen degradation.变形链球菌、放线菌属和牙龈卟啉单胞菌对胶原蛋白降解的影响。
Zhonghua Yi Xue Za Zhi (Taipei). 1999 Nov;62(11):764-74.
4
Fluoride, remineralization and root caries.氟化物、再矿化与根面龋
Am J Dent. 1994 Oct;7(5):271-4.
5
Effect of lactic acid and proteolytic enzymes on the release of organic matrix components from human root dentin.乳酸和蛋白水解酶对人牙根牙本质中有机基质成分释放的影响。
Caries Res. 1995;29(6):483-9. doi: 10.1159/000262119.
6
Development of multi-species consortia biofilms of oral bacteria as an enamel and root caries model system.作为牙釉质和根龋模型系统的口腔细菌多物种聚生体生物膜的开发。
Arch Oral Biol. 2000 Jan;45(1):27-40. doi: 10.1016/s0003-9969(99)00111-9.
7
In vitro evaluation of secondary caries development in enamel and root dentin around luted metallic restoration.金属粘结修复体周围釉质和根部牙本质继发龋发展的体外评估
Oper Dent. 2001 Jan-Feb;26(1):52-9.
8
Study of root caries in an artificial mouth.人工口腔中根龋的研究。
N Z Dent J. 1998 Jun;94(416):62-4.
9
Human root caries: microbiota of a limited number of root caries lesions.人类根龋:少数根龋病变的微生物群
Caries Res. 1996;30(1):52-64. doi: 10.1159/000262137.
10
The microbiology and histopathology of human root caries.人类根龋的微生物学与组织病理学
Am J Dent. 1995 Dec;8(6):323-8.

引用本文的文献

1
Gene expression of bacterial collagenolytic proteases in root caries.根龋中细菌胶原溶解蛋白酶的基因表达
J Oral Microbiol. 2018 Jan 18;10(1):1424475. doi: 10.1080/20002297.2018.1424475. eCollection 2018.
2
Filifactor alocis collagenase can modulate apoptosis of normal oral keratinocytes.牙龈纤毛菌胶原酶可调节正常口腔角质形成细胞的凋亡。
Mol Oral Microbiol. 2017 Apr;32(2):166-177. doi: 10.1111/omi.12163. Epub 2016 Jul 6.
3
The collagen binding protein Cnm contributes to oral colonization and cariogenicity of Streptococcus mutans OMZ175.
胶原蛋白结合蛋白Cnm有助于变形链球菌OMZ175在口腔中的定殖和致龋性。
Infect Immun. 2015 May;83(5):2001-10. doi: 10.1128/IAI.03022-14. Epub 2015 Mar 2.