Sapian-Raczkowska B, Adamiec R, Zdrojowy K, Masłowski L
Katedra i Klinika Angiologii AM we Wrocławiu.
Pol Merkur Lekarski. 1999 Jul;7(37):12-3.
Lipoprotein(a) [Lp(a)] is the specific lipoprotein which physiological role has not been explained. Similarity between apolipoprotein(a) and plasminogen structure suggests, that Lp(a) can be the bridge connecting the lipid metabolism and the coagulation system. The aim of the study was to evaluate if there is any correlation between Lp(a) and plasminogen serum concentrations in patients with diabetes t.2. 20 males and females with diabetes t.2 in the age 19-75 years (mean: 54.9 years). The control group consisted of 15 healthy men and woman in the age of 23 years (medical students). Lp(a) was estimated by ELISA, plasminogen by turbidimetric methods. Lp(a) serum level in the examined group was: 40.06 + 59.45 mg%. In 7 patients it was over 30 mg%. In the control group: Lp(a) concentration was: 13.23 + 10.5 mg%, no one was above 30 mg%. The different was significant. Plasminogen concentration was: in patients: 94.08 + 53.08%, in the control group: 89.08 + 40.7%. There was no significant difference. Correlation index between Lp(a) and plasminogen concentrations was in the patient's group: 0.3, in the control group: 0.2. In patients with diabetes we can find increased Lp(a) commentation in serum and normal plasminogen concentration. Concentration of Lp(a) didn't demonstrate significant correlation with plasminogen serum level.
脂蛋白(a)[Lp(a)]是一种生理作用尚未明确的特殊脂蛋白。载脂蛋白(a)与纤溶酶原结构相似，这表明Lp(a)可能是连接脂质代谢和凝血系统的桥梁。本研究的目的是评估2型糖尿病患者中Lp(a)与血清纤溶酶原浓度之间是否存在相关性。研究对象为20名年龄在19至75岁（平均54.9岁）的2型糖尿病男性和女性。对照组由15名年龄为23岁的健康男性和女性（医学生）组成。采用酶联免疫吸附测定法(ELISA)检测Lp(a)，用比浊法检测纤溶酶原。检测组的Lp(a)血清水平为：40.06±59.45mg%。7名患者的Lp(a)水平超过30mg%。对照组中，Lp(a)浓度为：13.23±10.5mg%，无人超过30mg%。差异具有显著性。纤溶酶原浓度为：患者组94.08±53.08%，对照组89.08±40.7%。无显著差异。患者组中Lp(a)与纤溶酶原浓度的相关指数为0.3，对照组为0.2。在糖尿病患者中，血清Lp(a)水平升高而纤溶酶原浓度正常。Lp(a)浓度与血清纤溶酶原水平未显示出显著相关性。
