Tarkun I, Cetinarslan B, Cantürk Z
Department of Endocrinology and Metabolism, Kocaeli University, Izmit, Turkey.
Nutr Metab Cardiovasc Dis. 2002 Jun;12(3):127-31.
Diabetes mellitus is associated with a 3-4 times greater risk of coronary artery disease. One of the major risk factors in diabetics is their abnormal plasma lipid and lipoprotein levels, and a high serum concentration of lipoprotein(a) [Lp(a)] is an acknowledged risk factor for atherosclerosis. The aim of this study was to evaluate serum Lp(a) levels in type 2 diabetic (T2DM) patients without cardiovascular disease, and assess the relationship between these levels and microvascular complications.
The study involved 86 T2DM patients without cardiovascular disease and 44 healthy control subjects. There were no statistically significant differences between the two groups in terms of mean age, body mass index, total cholesterol, low density lipoprotein-cholesterol or Lp(a) levels. There was a positive correlation between Lp(a) levels and diabetic proliferative retinopathy. Microalbuminuria and serum Lp(a) concentrations were significantly higher in the T2DM patients with proliferative retinopathy, who also had a longer duration of diabetes.
Diabetes does not increase serum Lp(a) concentrations. T2DM patients with high Lp(a) levels may be at high risk of retinopathy.
糖尿病患者患冠状动脉疾病的风险比常人高3至4倍。糖尿病患者的主要风险因素之一是其血浆脂质和脂蛋白水平异常，而血清脂蛋白(a)[Lp(a)]浓度升高是公认的动脉粥样硬化风险因素。本研究旨在评估无心血管疾病的2型糖尿病（T2DM）患者的血清Lp(a)水平，并评估这些水平与微血管并发症之间的关系。
本研究纳入了86例无心血管疾病的T2DM患者和44例健康对照者。两组在平均年龄、体重指数、总胆固醇、低密度脂蛋白胆固醇或Lp(a)水平方面无统计学显著差异。Lp(a)水平与糖尿病增殖性视网膜病变呈正相关。增殖性视网膜病变的T2DM患者的微量白蛋白尿和血清Lp(a)浓度显著更高，且糖尿病病程更长。
糖尿病不会增加血清Lp(a)浓度。Lp(a)水平高的T2DM患者可能有较高的视网膜病变风险。
